- CAS
- Purity
- 13509-52-9
- 99%
Manufacturer supply 1,3,4-TRIMETHYL URACIL 13509-52-9 with sufficient stock and high standard
- Molecular Formula: C7H10 N2 O2
- Molecular Weight: 154.169
- Vapor Pressure: 0.104mmHg at 25°C
- Melting Point: 114-115℃
- Boiling Point: 222.1°Cat760mmHg
- Flash Point: 87.8°C
- PSA： 44.00000
- Density: 1.16g/cm3
- LogP: -0.60760
1,3,4-TRIMETHYL URACIL(Cas 13509-52-9) Usage
|
General Description |
1,3,4-Trimethyluracil, also known as TMU, is a chemical compound that occurs naturally in the human body and can also be produced synthetically. It is a derivative of the nucleotide uracil and belongs to the class of pyrimidine compounds. TMU has been studied for its potential therapeutic properties, including its ability to act as a neuroprotective agent and to improve cognitive function. It is also being investigated for its role in promoting wound healing and reducing inflammation. Additionally, TMU has been explored for its potential use in the treatment of various medical conditions, including ischemic stroke, diabetic neuropathy, and traumatic brain injury. Its unique chemical structure and biological activities make TMU an interesting compound for further research and potential pharmaceutical development. |
InChI:InChI=1/C7H10N2O2/c1-5-4-6(10)9(3)7(11)8(5)2/h4H,1-3H3
13509-52-9 Relevant articles
Photoinduced electron transfer to pyrimidines and 5,6-dihydropyrimidine derivatives: Reduction potentials determined by fluorescence quenching kinetics
Scannell, Michael P.,Prakash, Gautam,Falvey, Daniel E.
, p. 4332 - 4337 (1997)
The dynamics of flourescence quenching o...
-
Reznik et al.
, (1968)
-
Antiparasitic activity of highly conjugated pyrimidine-2,4-dione derivatives
Azas, Nadine,Rathelot, Pascal,Djekou, Serge,Delmas, Florence,Gellis,Di Giorgio, Carole,Vanelle, Patrice,Timon-David, Pierre
, p. 1263 - 1270 (2003)
4-[2-(1,3-Dimethyl-5-nitro-2,6-dioxo-1,2...
Unlocking Access to Enantiopure Fused Uracils by Chemodivergent [4+2] Cross-Cycloadditions: DFT-Supported Homo-Synergistic Organocatalytic Approach
Battistini, Lucia,Curti, Claudio,Lombardo, Marco,Pelosi, Giorgio,Pinna, Luigi,Rassu, Gloria,Sartori, Andrea,Zambrano, Vincenzo,Zanardi, Franca
, p. 20055 - 20064 (2020)
The discovery of chemical methods enabli...
Hetero-Diels-Alder cycloadditions of α,β-unsaturated acyl cyanides. Part 2. Reactions with N,N-dimethyluracils, a new route to 5-substituted uracil derivatives
Zhuo,Wyler
, p. 1916 - 1927 (1993)
-
A potent and selective inhibition of parainfluenza 1 (Sendai) virus by new 6-oxiranyl-, 6-methyloxiranyluracils, and 4(3H)-pyrimidinone derivatives
Saladino, Raffaele,Danti, Maria Chiara,Mincione, Enrico,Crestini, Claudia,Palamara, Anna Teresa,Savini, Patrizia,Marini, Stefano,Botta, Maurizio
, p. 1833 - 1838 (1998)
Several new 6-oxiranyl-, 6-methyloxirany...
-
Case,Hill
, p. 1536,1540 (1930)
-
Effect of a cobalt(II) complex on the radical reaction of vinyl type sulfides. A 'radico-catalysis'
Tada, Masaru,Uetake, Tomohiro,Hanaoka, Yoshinobu
, p. 75 - 76 (1999)
Vinyl type sulfides show increased radic...
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Khattak,Wang
, p. 945,946,950,951-953 (1972)
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Skeletally Diverse Synthesis of Innovative [2,1-c]-1,4-Oxazepine and [1,4]-Quinoxaline Systems
Lee, Chia-Hsin,Wu, Wen-Chun,Dangate, Prasad S.,Shen, Li-Ching,Chung, Wen-Sheng,Sun, Chung-Ming
, p. 623 - 630 (2015)
An efficient, innovative synthesis of [2...
Highly Efficient Synthesis of Substituted 3,4-Dihydropyrimidin-2-(1H)-ones (DHPMs) Catalyzed by Hf(OTf)4: Mechanistic insights into reaction pathways under metal Lewis acid catalysis and solvent-free conditions
Kong, Rui,Han, Shuai-Bo,Wei, Jing-Ying,Peng, Xiao-Chong,Xie, Zhen-Biao,Gong, Shan-Shan,Sun, Qi
, (2019/02/01)
In our studies on the catalytic activity...
Reaction of Halogenated Uracils with KI
Chernikova,Spirikhin,Abdullin,Yunusov
, p. 1140 - 1143 (2017/11/27)
Treatment of 5-iodo-1,3,6-trimethyluraci...
13509-52-9 Process route
-
-
626-48-2
6-Methyluracil
-
-
77-78-1
dimethyl sulfate
-
-
13509-52-9
1,3,6-trimethyluracil
Conditions
| Conditions | Yield |
|---|---|
|
With
sodium hydroxide;
In
water;
at 25 ℃;
for 72h;
|
98%
|
|
6-Methyluracil;
With
potassium carbonate;
In
acetone;
at 20 ℃;
for 0.5h;
Inert atmosphere;
dimethyl sulfate;
In
acetone;
at 60 ℃;
for 8h;
Inert atmosphere;
|
98%
|
|
6-Methyluracil;
With
potassium carbonate;
In
acetone;
at 25 ℃;
for 0.333333h;
dimethyl sulfate;
In
acetone;
at 60 ℃;
for 11h;
Reagent/catalyst;
Solvent;
Temperature;
|
96%
|
|
With
sodium hydroxide;
Heating;
|
92%
|
|
With
sodium hydroxide;
at 100 ℃;
for 4h;
|
90%
|
|
With
sodium hydroxide;
In
water;
Ambient temperature;
|
83%
|
|
6-Methyluracil;
With
sodium hydroxide;
at 70 ℃;
dimethyl sulfate;
at 80 ℃;
for 1h;
|
70%
|
|
With
sodium hydroxide;
In
water;
at 40 ℃;
|
43%
|
|
With
potassium hydroxide;
at 25 - 30 ℃;
|
|
|
With
sodium hydroxide;
|
|
|
|
|
|
With
sodium hydroxide;
|
-
-
96-31-1
N,N'-Dimethylurea
-
-
108-24-7
acetic anhydride
-
-
13509-52-9
1,3,6-trimethyluracil
Conditions
| Conditions | Yield |
|---|---|
|
With
dmap;
In
pyridine;
for 2h;
Ambient temperature;
|
83%
|
|
With
pyridine;
at 0 - 26 ℃;
|
|
|
With
pyridine; dmap;
at 0 - 20 ℃;
|
|
|
With
pyridine; dmap;
at 20 ℃;
for 3h;
Inert atmosphere;
|
|
|
With
pyridine; dmap;
In
pyridine;
at 20 ℃;
for 3h;
Inert atmosphere;
|
13509-52-9 Upstream products
-
186581-53-3
diazomethane
-
626-48-2
6-Methyluracil
-
77-78-1
dimethyl sulfate
-
74-88-4
methyl iodide
13509-52-9 Downstream products
-
100870-67-5
1,3-dimethyl-6-phenacyl-1H -pyrimidine-2,4-dione
-
15018-59-4
5-bromo-1,3,6-trimethylpyrimidine-2,4(1 H,3H)-dione
-
55326-07-3
1,3,6-trimethyl-5-nitrouracil
-
84174-94-7
5-(4-Bromo-1-methyl-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl)-1,3,6-trimethyl-1H-pyrimidine-2,4-dione