- CAS
- Purity
- 550-33-4
- 99%
Buy Quality NEBULARINE 550-33-4 In Stock with Immediately Delivery
- Molecular Formula:C10H12 N4 O4
- Molecular Weight:252.23
- Vapor Pressure:7.71E-15mmHg at 25°C
- Melting Point:181-182°C
- Refractive Index:1.6500 (estimate)
- Boiling Point:591.6°Cat760mmHg
- PKA:13.13±0.70(Predicted)
- Flash Point:311.6°C
- PSA：113.52000
- Density:1.91g/cm3
- LogP:-1.56220
NEBULARINE(Cas 550-33-4) Usage
|
Purification Methods |
Nebularine is recrystallised from butanone/MeOH or EtOH and forms a MeOH photo-adduct. It is a strong inhibitor of adenosine deaminase [EC 3.5.4.4]. [Nair & Weichert Bioorg Chem 9 423 1980, Lfgren et al. Acta Chem Scand 7 225 1953, UV: Brown & Weliky J Biol Chem 204 1019 1953, Beilstein 26 III/IV 1740.] |
|
Definition |
ChEBI: A purine ribonucleoside that is 9H-purine attached to a beta-D-ribofuranosyl residue at position 9 via a glycosidic (N-glycosyl) linkage. |
InChI:InChI=1/C10H12N4O4/c15-2-6-7(16)8(17)10(18-6)14-4-13-5-1-11-3-12-9(5)14/h1,3-4,6-8,10,15-17H,2H2/t6-,7+,8-,10+/m1/s1
550-33-4 Relevant articles
Antiviral, metabolic, and pharmacokinetic properties of the isomeric dideoxynucleoside 4(S)-(6-amino-9H-purin-9-yl)tetrahydro-2(S)-furanmethanol
Nair,St. Clair,Reardon,Krasny,Hazen,Paff Lawrence,Boone,Tisdale,Najera,Dornsife,Averett,Borroto-Esoda,Yale,Zimmerman,Rideout
, p. 1993 - 1999 (1995)
4(S)-(6-Amino-9H-purin-9-yl)tetrahydro-2...
CYCLIC DINUCLEOTIDES AS STING AGONISTS
-
Page/Page column 204-206, (2019/07/19)
Disclosed are compounds, compositions an...
The synthesis of nebularine and its analogs via oxidative desulfuration in aqueous nitric acid
Xia, Ran,Sun, Li-Ping,Qu, Gui-Rong
supporting information, p. 88 - 91 (2016/12/24)
The synthesis of nebularine and its anal...
Efficient synthesis of nebularine and vidarabine via dehydrazination of (hetero)aromatics catalyzed by CuSO4 in water
Xia, Ran,Xie, Ming-Sheng,Niu, Hong-Ying,Qu, Gui-Rong,Guo, Hai-Ming
, p. 1077 - 1081 (2014/03/21)
A simple dehydrazination reaction has be...
High-throughput five minute microwave accelerated glycosylation approach to the synthesis of nucleoside libraries
Bookser, Brett C.,Raffaele, Nicholas B.
, p. 173 - 179 (2007/10/03)
The Vorbrueggen glycosylation reaction w...
550-33-4 Process route
-
-
1-aminoadenosinium mesitylenesulphonate
-
-
550-33-4
Nebularin
-
-
58-61-7
adenosine
Conditions
| Conditions | Yield |
|---|---|
|
With
ammonia;
In
methanol;
at 80 ℃;
for 10h;
|
60% 20% |
|
With
ammonia;
In
methanol;
at 80 ℃;
for 10h;
Mechanism;
also with 15N-labelled compounds, also with the 2',3'-O-isopropylidene derivative, deamination reaction;
|
60% 20% |
-
-
5746-27-0
N6-aminoadenosine
-
-
58-63-9
Inosine
-
-
550-33-4
Nebularin
-
-
58-61-7
adenosine
Conditions
| Conditions | Yield |
|---|---|
|
With
ammonia;
In
methanol;
|
15% 35% 40% |
550-33-4 Upstream products
-
2004-06-0
6-Chloropurine riboside
-
5466-11-5
2-Chloro-purine riboside
-
79366-24-8
9-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-9H-purine
-
15981-63-2
2',3',5'-tri-O-acetylnebularine
550-33-4 Downstream products
-
29618-02-8
6-(hydroxymethyl)-9-(β-D-ribofuranosyl)purine
-
29699-93-2
6(R)-hydroxymethyl-9-β-D-ribofuranosyl-1,6-dihydropurine
-
29700-19-4
6(S)-hydroxymethyl-9-β-D-ribofuranosyl-1,6-dihydropurine
-
13754-19-3
4,5-pyrimidinediamine