- CAS
- Purity
- 42258-90-2
- 99%
Location：Home > Organic Chemicals
Manufacturer supply top purity methyl (R)-thiazolidine-4-carboxylate 42258-90-2 with ISO standards
- Molecular Formula: C5H9NO2S
- Molecular Weight: 147.198
- Vapor Pressure: 0.0413mmHg at 25°C
- Refractive Index: 1.507
- Boiling Point: 238.9 °C at 760 mmHg
- Flash Point: 98.3 °C
- PSA： 63.63000
- Density: 1.208 g/cm3
- LogP: 0.15070
methyl (R)-thiazolidine-4-carboxylate(Cas 42258-90-2) Usage
|
General Description |
Methyl (R)-thiazolidine-4-carboxylate is a chemical compound that is derived from thiazolidine-4-carboxylic acid. It is commonly used as a building block in the synthesis of pharmaceuticals and other organic compounds. methyl (R)-thiazolidine-4-carboxylate has a thiazolidine ring structure, containing a sulfur atom and a carbon-carbon double bond, and is chiral, meaning it has a non-superimposable mirror image. The (R) configuration in the name indicates the stereochemistry of the molecule, specifying the spatial arrangement of its atoms. Methyl (R)-thiazolidine-4-carboxylate is known for its potential pharmacological activity, particularly in the development of drugs targeting conditions such as diabetes and obesity. Its unique structure and properties make it a valuable tool in the field of medicinal chemistry and drug discovery. |
InChI:InChI=1/C5H9NO2S/c1-8-5(7)4-2-9-3-6-4/h4,6H,2-3H2,1H3/t4-/m0/s1
42258-90-2 Relevant articles
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Northrop,R.C.,Russ,P.L.
, p. 558 - 559 (1975)
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Stereochemical study of 1,3-N,X-heterocycles derived from α-aminoacids and formaldehyde. Structural evidence for the existence of the anomeric effect
Sélambarom, Jimmy,Carré, Francis,Fruchier, Alain,Roque, Jean Pierre,Pavia, André A
, p. 4439 - 4444 (2002)
We have shown that condensation of L-cys...
Method for preparing thiazole-4-formic acid
-
Paragraph 0021; 0024-0025; 0031; 0034-0035; 0041; 0044-0045, (2019/04/17)
The invention discloses a method for pre...
D-Penicillamine and L-cysteine derived thiazolidine catalysts: an efficient approach to both enantiomers of secondary alcohols
Serra, M. Elisa Silva,Costa, Dora,Murtinho, Dina,Tavares, Nélia C.T.,Pinho e Melo, Teresa M.V.D.
, p. 5923 - 5927 (2016/09/07)
D-Penicillamine derived thiazolidine lig...
New functionalized 8-hydroxyquinoline-5-sulfonic acid mesoporous silica (HQS-SBA-15) as an efficient catalyst for the synthesis of 2-thiohydantoin derivatives
Vavsari, Vaezeh Fathi,Ziarani, Ghodsi Mohammadi,Balalaie, Saeed,Latifi, Arezoo,Karimi, Mehdi,Badiei, Alireza
supporting information, p. 5420 - 5426 (2016/08/05)
Mesoporous silica SBA-15 functionalized ...
Thiazolidine esters: New potent urease inhibitors
Lodhi, Muhammad Arif,Shams, Sulaiman,Khan, Khalid Mohammad
, p. 858 - 864 (2015/01/30)
A variety of esters of thiazolidine-4-ca...
42258-90-2 Process route
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67-56-1
methanol
-
-
34592-47-7,2756-91-4,6070-92-4,60731-25-1
L-thioproline
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-
42258-90-2
(R)-thiazolidine-4-carboxylic acid methyl ester
Conditions
| Conditions | Yield |
|---|---|
|
With
hydrogenchloride;
at 30 ℃;
for 14h;
Temperature;
|
89.1%
|
|
methanol; L-thioproline;
With
thionyl chloride;
at 0 ℃;
for 12h;
With
sodium hydrogencarbonate;
In
water;
|
82%
|
|
With
thionyl chloride;
1.) -20 deg C, 30 min, 2.) RT, 6 h;
|
79%
|
|
With
thionyl chloride;
7 h, room temp., 1 h, reflux;
|
76.5%
|
|
With
thionyl chloride;
at -10 ℃;
for 24h;
|
-
-
50-00-0,30525-89-4,61233-19-0
formaldehyd
-
-
18598-63-5
L-cysteine methyl ester hydrochloride
-
-
42258-90-2
(R)-thiazolidine-4-carboxylic acid methyl ester
Conditions
| Conditions | Yield |
|---|---|
|
With
triethylamine;
In
dichloromethane;
at 20 ℃;
|
60%
|
|
With
sodium hydrogencarbonate;
for 2h;
Ambient temperature;
|
55%
|
|
L-cysteine methyl ester hydrochloride;
With
potassium hydrogencarbonate;
In
ethanol; water;
at 20 ℃;
formaldehyd;
In
ethanol; water;
at 20 ℃;
|
42258-90-2 Upstream products
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34592-47-7
L-thioproline
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186581-53-3
diazomethane
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67-56-1
methanol
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50-00-0
formaldehyd
42258-90-2 Downstream products
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105126-44-1
(R)-6-(4-Chloro-phenyl)-dihydro-imidazo[1,5-c]thiazole-5,7-dione
-
51977-23-2
6,8-dioxo-7-phenyl-3-thia-1,7-diazabicyclo <3.3.0> octane
-
105126-42-9
(R)-6-p-Tolyl-dihydro-imidazo[1,5-c]thiazole-5,7-dione
-
105126-43-0
(R)-6-(4-Methoxy-phenyl)-dihydro-imidazo[1,5-c]thiazole-5,7-dione